SAR439859+哌柏西利作为ER（+）HER2（-）晚期乳腺癌患者的一线治疗

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试验详情

一、临床试验项目名称
SAR439859+哌柏西利作为ER（+）HER2（-）晚期乳腺癌患者的一线治疗

二、适应症
ER（+）HER2（-）晚期乳腺癌

三、试验介绍

主要目的：确定与来曲唑联合哌柏西利相比，SAR439859联合哌柏西利是否可以改善在复发转移阶段未接受过全身性抗癌治疗的ER+HER2-晚期乳腺癌受试者的无进展生存期（PFS）次要目的：比较两个治疗组的总生存期（OS）；评价两个治疗组的客观缓解率（ORR）；评价两个治疗组的缓解持续时间（DOR）；评价两个治疗组的临床获益率（CBR）；评价SAR439859、戈舍瑞林和哌柏西利的药代动力学（PK）; 评价两个治疗组的健康相关生活质量（HRQL）; 评价两个治疗组至首次化疗的时间; 评价两个治疗组的安全性

研究中心所在省份及城市（具体启动情况以后期咨询为准）

研究中心	主要研究者
复旦大学附属肿瘤医院	邵志敏

序号	机构名称	主要研究者	国家	省（州）	城市
1	复旦大学附属肿瘤医院	邵志敏	中国	上海市	上海市
2	浙江大学医学院附属邵逸夫医院	王娴	中国	浙江省	杭州市
3	吉林大学第一医院	李薇	中国	吉林省	长春市
4	吉林省肿瘤医院	程颖	中国	吉林省	长春市
5	浙江省肿瘤医院	王晓稼	中国	浙江省	杭州市
6	浙江大学医学院附属第一医院	傅佩芬	中国	浙江省	杭州市
7	浙江大学医学院附属第二医院	黄建	中国	浙江省	杭州市
8	北京肿瘤医院	李惠平	中国	北京市	北京市
9	复旦大学附属中山医院	张宏伟	中国	上海市	上海市
10	哈尔滨医科大学附属肿瘤医院	张清媛	中国	黑龙江省	哈尔滨市
11	江苏省人民医院	殷咏梅	中国	江苏省	南京市
12	四川大学华西医院	罗婷	中国	四川省	成都市
13	中山大学孙逸仙纪念医院	刘强	中国	广东省	广州市
14	苏州大学附属第二医院	庄志祥	中国	江苏省	苏州市
15	临沂市肿瘤医院	王京芬	中国	山东省	临沂市
16	济南市中心医院	孙玉萍	中国	山东省	济南市
17	重庆大学附属肿瘤医院	曾晓华	中国	重庆市	重庆市
18	安徽省立医院	潘跃银	中国	安徽省	合肥市
19	大连医科大学附属第二医院	李曼	中国	辽宁省	大连市
20	河南省肿瘤医院	闫敏	中国	河南省	郑州市
21	湖北省肿瘤医院	吴新红	中国	湖北省	武汉市
22	广东省人民医院	廖宁	中国	广东省	广州市
23	徐州市中心医院	孙三元	中国	江苏省	徐州市
24	天津市肿瘤医院	张瑾	中国	天津市	天津市
25	中山大学肿瘤防治中心	王树森	中国	广东省	广州市
26	Instituto de Investigaciones Metabólicas IDIM	Cundom Juan	ARGENTINA	AR-B	CABA
27	Breast Cancer Research Centre	CHAN ARLENE	AUSTRALIA	VIC	Richmond
28	Epworth Healthcare	JENNENS Ross	AUSTRALIA	NSW	Wahroonga
29	Sydney Adventist Hospital	Marx Gavin	AUSTRALIA	NSW	Macquarie Park
30	Macquarie University	Sabanathan Dhanusha	AUSTRALIA	NSW	Macquarie Park
31	Prince Of Wales Hospital	FRIEDLANDER Michael	AUSTRIA	NSW	Randwick
32	Universitatsklinikum Graz	Petru Edgar	BELGIUM	NA	Graz
33	UZ Leuven	Neven Patrick	BELGIUM	NA	Leuven
34	CHU UCL Namur	Taylor donatienne	BELGIUM	NA	Namur
35	Clinques Universitaires Saint-Luc	Duhoux Francois	BELGIUM	NA	Bruxelles
36	Grand Hospital de Charleroi Site Notre Dame	Canon Jean-Luc	BELGIUM	NA	Charleroi
37	Hospital De Caridade De Ijui	Franke Fabio Andre	BRAZIL	BR-RS	Ijui
38	Instituto Brasileiro De Controle Do Cancer - IBCC	Cruz Felipe	BRAZIL	BR-SP	Sao Paulo
39	Instituto Nacional de Cancer - José Alencar Gomes da Silva	BINES Jose	BRAZIL	BR-RJ	Rio De Janeiro
40	Hospital De Clinicas De Porto Alegre	Liedke Pedro	BRAZIL	BR-RS	Porto Alegre
41	Hospital Nossa Senhora da Conceicao	Pedrini José Luiz	BRAZIL	BR-RS	Porto Alegre
42	Fundacao Antonio Prudente - Hospital A.C. Camargo	Pondé Noam	BRAZIL	BR-SP	Sao Paulo
43	REDE D′OR SAO LUIZ S.A.	Testa Laura	BRAZIL	BR-SP	Sao Paulo
44	Sunnybrook Research Institute	Warner Ellen	CANADA	CA-ON	Toronto
45	London Regional Cancer Program	Fernandes Ricardo	CANADA	CA-ON	London
46	Kingston General Hospital	Mates Mihaela	CANADA	CA-ON	Kingston
47	McGill University Health Centre - Glen Site - Centre for Innovative Medicine	Asselah Jamil	CANADA	CA-QC	Montreal
48	Moncton Hospital	Harb Mohammed	CANADA	CA-NB	Moncton
49	Centre Integre de Sante et de Services Sociaux de la Monteregie-Centre (CISSSMC)	Soldera Sara	CANADA	CA-QC	Greenfield Park
50	Ste-Mary's Hospital	Esfahani Khashayar	CANADA	CA-QC	Montreal
51	Cape Breton Cancer Centre	Saliba Wissam	CANADA	CA-NS	Sydney
52	Cape Breton Cancer Centre	Khodadad Kian	CANADA	CA-NS	Sydney
53	Jewish General Hospital	Ferrario Cristiano	CANADA	CA-QC	Montreal
54	ONCOCENTRO APYS	Acevedo Alejandro	CHILE	CL-VS	Via del Mar
55	Centro de Investigacion Clinica Bradford Hill	Rojas Carlos	CHILE	CL-RM	Santiago
56	Centro de Investigacion Clinica Bradford Hill	Burotto Mauricio	CHILE	CL-RM	Santiago
57	Centro de Investigación de la universidad Catolica	SANCHEZ CESAR	CHILE	NA	Santiago de Chile
58	Sociedad de Investigaciones medicas LTDA	Yanez Patricio	CHILE	CL-AR	Temuco
59	IC La Serena Research	Morales Luisa	CHILE	CL-CO	La Serena
60	Clinica Alemana de Santiago	Sola Jose	CHILE	CL-RM	Santiago
61	Clinica Alemana de Santiago	Salas Claudio	CHILE	CL-RM	Santiago
62	Fundacion Arturo Lopez Perez	Barajas Olga	CHILE	NA	Santiago
63	CLINICA UNIVERSIDAD CATOLICA DEL MAULE	Araya Hernan	CHILE	CL-ML	Talca
64	CLINICA UNIVERSIDAD CATOLICA DEL MAULE	Araya Hernan	CHILE	CL-ML	Talca
65	ICEGCLINIC	Garcia Eva	CHILE	CL-RM	Santaigo
66	National Taiwan University Hospital	Lu Yen-Shen	中国台湾	NA	Taipei
67	National Cheng Kung University Hospital	Chung Wei-Pang	中国台湾	NA	Tainan
68	Mackay Memorial Hospital	Chang Yuan-Ching	中国台湾	NA	Taipei
69	Chang Gung Memorial Hospital - Linkou	Chen Shih-Cheh	中国台湾	NA	Taoyuan
70	Taipei Veterans General Hospital	Tseng Ling-Ming	中国台湾	NA	Taipei
71	Changhua Christian Hospital	Chen Shou-Tung	中国台湾	NA	Changhua
72	Kaohsiung Medical University Chung-Ho Memorial Hospital	Hou Ming-Feng	中国台湾	NA	Kaohsiung
73	Masarykuv Onkologicky Ustav	Petrakova Katarina	CZECH REPUBLIC	NA	Brno
74	Vseobecna Fakultni Nemocnice V Praze	Zimovjanova Martina	CZECH REPUBLIC	NA	Praha 2
75	Onkologické centrum Multiscan	ODRAZKA Karel	CZECH REPUBLIC	NA	Pardubice
76	Rigshospitalet	KNOP Ann	DENMARK	NA	Kobenhavno
77	lborg Sygehus	Yammeni Sophie	DENMARK	NA	Alborg
78	Aarhus Universitetshospital Skejby	Jensen Anders	DENMARK	NA	Aarhus N
79	Sygehus Snderjylland Snderborg	Peric Jana	DENMARK	NA	Sonderborg
80	SA Phja-Eesti Regionaalhaigla	KüTNER Riina	ESTONIA	NA	Tallinn
81	SA Tartu ülikooli Kliinikum	Kallak Kersti	ESTONIA	NA	Tartu
82	HUS Sypkeskus	Karihtala Peeter	FINLAND	NA	Helsinki
83	Pirkanmaan sairaanhoitopiiri / Tays	Tanner Minna	FINLAND	NA	Tampere
84	Turun Yliopistollinen keskussairaala	Huovinen Riikka	FINLAND	NA	Turku
85	Vaasan keskussairaala	Jekunen Antti	FINLAND	NA	Vaasa
86	#Institut Curie - Site de Paris	Bidard Francois-Clement	FRANCE	NA	PARIS
87	#Hopital Saint Louis	TEIXEIRA Luis	FRANCE	NA	PARIS
88	#Gustave Roussy	Pistilli Barbara	FRANCE	NA	VILLEJUIF
89	Institut Claudius Regaud - IUCT-O	Dalenc Florence	FRANCE	NA	TOULOUSE Cedex 9
90	#CHU Poitiers - Hopital La Miletrie	Isambert Nicolas	FRANCE	NA	Poitiers
91	#CHU Poitiers - Hopital La Miletrie	ISAMBERT Nicolas	FRANCE	NA	Poitiers
92	#Institut Curie - Site St-Cloud	Bidard Francois-Clement	FRANCE	NA	SAINT CLOUD
93	#Centre Leon Berard	Bachelot Thomas	FRANCE	NA	Lyon
94	#Centre Antoine Lacassagne	FERRERO Jean Marc	FRANCE	NA	Nice
95	ICANS	PETIT Thierry	FRANCE	NA	STRASBOURG
96	Acad Fridon Todua Medical Center LTD -Research Institute of Clinical Medicine LTD	Melkadze Tamar	GEORGIA	NA	Tbilisi
97	Tbilisi State Medical University and Ingorokva High Medical Technology University Clinic LLC	Gogishvili Miranda	GEORGIA	NA	Tbilisi
98	LTD Multiprofile Clinic Consilium Medula	Sanikidze Spiridon	GEORGIA	NA	Tbilisi
99	LTD Tbilisi Oncology Dispensary	Sikharulidze Irakli	GEORGIA	NA	Tbilisi
100	LTD High Technology Hospital Medcentre	Smionova Nino	GEORGIA	NA	Batumi
101	JSC Evex Clinics	Qitiashvili Tariel	GEORGIA	NA	Kutaisi
102	LTD Institute of Clinical Oncology	Nemsadze Diana	GEORGIA	NA	Tbilisi
103	Universit？tsklinikum Ulm	Ernst Kristina	GERMANY	NA	Ulm
104	Mammazentrum Hamburg	Schem Christian	GERMANY	NA	Hamburg
105	Universit？tsklinikum Münster	Tio Joke	GERMANY	NA	Münster
106	Klinikum Oberberg GmbH	Weishap Anja	GERMANY	NA	Gummersbach
107	Szabolcs-Szatmár-Bereg Megyei Kórházak és Egyetemi Oktatókórház	Erfán József	HUNGARY	NA	Nyíregyháza
108	Debreceni Egyetem Klinikai K？zpont	árkosy Péter	HUNGARY	NA	Debrecen
109	Somogy Megyei Kaposi Mór Oktató Kórház	Bálint András	HUNGARY	NA	Kaposvár
110	Szent Margit Kórház	Boer Katalin	HUNGARY	NA	Budapest
111	Petz Aladár Megyei Oktató Kórház	Sip？cz István	HUNGARY	NA	Gyr
112	Szent Imre Egyetemi Oktatókórház	Nagy Zsuzsanna	HUNGARY	NA	Budapest
113	Bács-Kiskun Megyei Kórház a Szegedi Tudományegyetem általános Orvostudományi Kar Oktató Kórháza, Rendel？intézet	Horváth Zsolt	HUNGARY	NA	Kecskemét
114	Azienda Ospedaliera San Martino	Del Mastro Lucia	ITALY	IT-GE	Genova
115	Istituto Europeo di Oncologia	Colleoni Marco	ITALY	IT-MI	Milano
116	Istituto Clinico Humanitas	Torrisi Rosalba	ITALY	IT-MI	Rozzano
117	IRCCS Ospedale San Raffaele	Bianchini Giampaolo	ITALY	IT-MI	Milano
118	Nuovo Ospedale Santo Stefano	Biganzoli Laura	ITALY	IT-PO	Prato
119	Istituto Nazionale Tumori	De Laurentiis Michelino	ITALY	IT-NA	Napoli
120	Azienda Ospedaliera San Gerardo	CAZZANIGA MARINA	ITALY	IT-MB	Monza
121	Ist. Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST)	De Giorgi Ugo	ITALY	NA	Meldola (FC)
122	Ist. Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST)	De Giorgi Ugo	ITALY	NA	Meldola (FC)
123	National Hospital Organization Hokkaido Cancer Center	Takahashi Masato	JAPAN	NA	Sapporo-shi
124	National Cancer Center Hospital East	Mukohara Toru	JAPAN	NA	Kashiwa-shi
125	The Cancer Institute Hospital of JFCR	Kobayashi Takayuki	JAPAN	NA	Koto-ku
126	Showa University Hospital	Nakamura Seigo	JAPAN	NA	Shinagawa-ku
127	Kanagawa Cancer Center	Yamashita Toshinari	JAPAN	NA	Yokohama-shi
128	Aichi Cancer Center Hospital	IWATA Hisashi	JAPAN	PL-MZ	Nagoya-shi
129	National Hospital Organization Osaka National Hospital	Masuda Norikazu	JAPAN	PL-LD	Osaka-shi
130	Shikoku Cancer Center	Ohsumi Shozo	JAPAN	PL-WP	Matsuyama-shi
131	Hiroshima City Hiroshima Citizens Hospital	Itoh Mitsuya	JAPAN	PL-PM	Hiroshima-shi
132	Sagara Hospital	Taira Tetsuhiko	JAPAN	PL-ZP	Kagoshima-shi
133	Saitama Medical University International Medical Center	Osaki Akihiko	JAPAN	NA	Hidaka-shi
134	Yokohama Rosai Hospital	Chishima Takashi	JAPAN	NA	Yokohama-shi
135	Asan Medical Center	Jung KyungHae	KOREA, REPUBLIC OF	NA	Seoul
136	Samsung Medical Center	Park Yeonhee	KOREA, REPUBLIC OF	NA	Seoul
137	Seoul National University Hospital	Im Seock Ah	KOREA, REPUBLIC OF	NA	Seoul
138	Yonsei University Health System, Severance Hospital	Sohn JooHyuk	KOREA, REPUBLIC OF	NA	Seoul
139	Seoul National University Bundang Hospital	Jee Hyun Kim	KOREA, REPUBLIC OF	NA	Seongnam
140	National Cancer Center	LEE Keun Seok	KOREA, REPUBLIC OF	NA	Goyang-si
141	Korea University Anam Hospital	PARK Kyong Hwa	KOREA, REPUBLIC OF	NA	Krasnogorskiy district
142	CHA Bundang Medical Center, CHA University	Moon Yong Wha	KOREA, REPUBLIC OF	NA	Seongnam-si, Gyeonggi-do
143	The Catholic University of Korea, Seoul St. Mary's Hospital	Lee Jieun	KOREA, REPUBLIC OF	NA	Seochogu
144	“Hospital Universitario “Dr. José Eleuterio González”	Zayas-Villanueva Omar	MEXICO	MX-NLE	Monterrey
145	Arke SMO, S.A. de C.V	Navarrete-Aleman Jaime	MEXICO	MX-VER	Veracruz
146	Health Pharma Professional Research S.A. De C.V	Perez Perez Perla	MEXICO	MX-MEX	Benito Juarez
147	Unidad de Investigación Cima, S.C.	Aguayo Yong Rocio	MEXICO	MX-CHH	Chihuahua
148	Maastricht UMC+	Tjan-Heijnen Vivianne	NETHERLANDS	NA	Maastricht
149	Spaarne Ziekenhuis	Kuijer Philomeen	NETHERLANDS	NA	Hoofddorp
150	Reinier De Graaf Gasthuis	Mammatas Lemonitsa	NETHERLANDS	NA	Delft
151	Ziekenhuis Rijnstate	Beelen Karin	NETHERLANDS	NA	Arnhem
152	Amphia Ziekenhuis Molengracht	HEIJNS Joan	NETHERLANDS	NA	Breda
153	Narodowy Instytut Onkologii	Nowecki Zbigniew	POLAND	PL-MZ	Warszawa
154	Specjalistyczny Szpital Onkologiczny NU-MED	CHMIELOWSKA Ewa	POLAND	PL-LD	Tomaszow Mazowiecki
155	Centrum Medyczne HCP	Kobylarek Robert	POLAND	PL-WP	Poznan
156	Szpitale Pomorskie Sp. z o.o.	Danielewicz Iwona	POLAND	PL-PM	Gdynia
157	Zachodniopomorskie Centrum Onkologii	TALERCZYK Malgorzata	POLAND	PL-ZP	Szczecin
158	Centro Hospitalar Lisboa Norte, E.P.E. – Hospital de Santa Maria	Costa Luis	PORTUGAL	NA	Lisboa
159	Centro Hospitalar Lisboa Norte, E.P.E. – Hospital de Santa Maria	Abreu Catarina	PORTUGAL	NA	Lisboa
160	Centro Hospitalar Lisboa Norte, E.P.E. – Hospital de Santa Maria	COSTA Lígia	PORTUGAL	NA	Lisboa
161	HOSPITAL DE SAO JOAO	Augusto Isabel	PORTUGAL	NA	PORTO
162	Centro Hospitalar do Porto - Hospital de Santo António	AFONSO Noémia	PORTUGAL	NA	PORTO
163	Hospital Garcia de Orta, EPE	Dias ？ngela	PORTUGAL	NA	Almada
164	Clinical Scientific and practical center for special types of medical care (oncology-oriented)	Chubenko Vyacheslav	RUSSIAN FEDERATION	NA	Saint -Petersburg
165	LLC	Moisseev Alexey	RUSSIAN FEDERATION	NA	Moscow
166	State Health Care Institution	Stroyakovskiy Daniil	RUSSIAN FEDERATION	NA	Krasnogorskiy district
167	FSBI National medical research center for obstetrics, gynecology and perinatalogy n.a. Kulakov MoH of Russian Federation	Khokhlova Svetlana	RUSSIAN FEDERATION	NA	Moscow
168	City clinical oncology hospital #1	Pokataev Ilya	RUSSIAN FEDERATION	NA	Moscow
169	Arkhangelsk Clinical oncological dispensary	Nechaeva Marina	RUSSIAN FEDERATION	NA	Arkhangelsk
170	N.N. Blokhin National Medical Research Center of Oncology？ оf the Ministry of Health of the Russian Federation	Artamonova Elena	RUSSIAN FEDERATION	NA	Moscow
171	Join Stock Company “MEDSI group”,Clinical Hospital #1	Mochalova Anastasia	RUSSIAN FEDERATION	NA	Moscow Region
172	AV Medical group	Shemerovskiy Alexander	RUSSIAN FEDERATION	NA	Saint Petersburg
173	Curie Oncology	Ngo Lynette	SINGAPORE	NA	Singapore
174	National University Hospital	Lee Soo Chin	SINGAPORE	NA	Singapore
175	Tan Tock Seng hospital	Heong Valerie	SINGAPORE	NA	Singapore
176	National Cancer Centre	Yap Yoon Sim	SINGAPORE	NA	Singapore
177	Hospital Universitario 12 de Octubre.	Ciruelos Gil Eva	SPAIN	NA	Madrid Madrid
178	Hospital Universitario HM Sanchinarro	Vega Alonso Estela	SPAIN	ES-MD	Madrid / Madrid
179	Hospital Clínico Universitario de Santiago-CHUS.	Lopez Rafael	SPAIN	ES-GA	Santiago de Compostela
180	Hospital Universitario La Paz.	ZAMORA Pilar	SPAIN	ES-M	Madrid
181	Hospital Clinico Universitario de Valencia	Bermejo Begoa	SPAIN	ES-VC	Valencia / Valencia
182	Hospital General Universitario Gregorio Mara？ón.	JEREZ GILARRANZ YOLANDA	SPAIN	ES-MD	Madrid / Madrid
183	Hospital Virgen de la Victoria	RIBELLES Nuria	SPAIN	ES-MA	Málaga
184	Consorci Corporació Sanitària Parc Taulí de Sabadell.	FERNANDEZ-MORALES LUIS	SPAIN	ES-CL	Barcelona / Sabadell
185	Hospital Universitari Arnau de Vilanova.	Llombart Cussac Antonio	SPAIN	ES-CL	Lleida / Lleida
186	Institut Dexeus	Pérez García Jose Manuel	SPAIN	ES-B	Barcelona
187	Medipol Mega üniversite Hastanesi	Bilici Ahmet	TURKEY	NA	Istanbul
188	NNü üNVERSTES TURGUT ZAL TIP MERKE	Harputluoglu Hakan	TURKEY	NA	Malatya
189	Trakya University Medicine Faculty	CICIN IRFAN	TURKEY	NA	Edirne
190	Istanbul Medeniyet Universitesi Goztepe EAH	Gumus Mahmut	TURKEY	NA	Istanbul
191	Ege Universitesi Tip Fakultesi	Gokmen Erhan	TURKEY	NA	Bornova
192	Baskent Universitesi Adana Uygulama Ve Arastirma Hastanesi	ozyilkan ozgur	TURKEY	NA	Adana
193	Akdeniz üniversitesi Hastanesi	Goksu Sema	TURKEY	NA	Antalya
194	Hacettepe Universitesi Onkoloji Enstitusu	aksoy sercan	TURKEY	NA	Ankara
195	Dr. Abdurrahman Yurtaslan Ankara Onkoloji E？itim ve Ara？t？rma Hastanesi	Oksuzoglu Berna	TURKEY	NA	Ankara
196	Kocaeli üniversitesi Aratrma ve Uygulama Hastanesi	Cabuk Devrim	TURKEY	NA	Kocaeli
197	Acbadem Maslak Hastanesi	ERALP Yesim	TURKEY	NA	Istanbul
198	zmir Ekonomi üniversitesi Medcal Park Hastanesi	Arslan Cagatay	TURKEY	NA	zmir
199	Dicle üniversitesi Tp Fakültesi Tbbi Onkoloji Anabilim Dal？	Kaplan Muhammet Ali	TURKEY	NA	Diyarbakr
200	Communal enterprise	Adamchuk Hryhoriy	UKRAINE	NA	Kryvyi Rih
201	Odesa Regional Clinical Hospital	Berzoy Oleksandr	UKRAINE	NA	Odesa
202	State institution V.T. Zaycev Institute of general and urgent surgery of National academy medical sciences of Ukraine	Dudnichenko Oleksandr	UKRAINE	NA	Kharkiv
203	Podillia Regional Oncology Center of Vinnytsia Regional Council	Shevnia Serhii	UKRAINE	NA	Vinnytsia
204	Regional Clinical SpecializedDispensary for Radiation Protection of Citizenry	Neffa Maryna	UKRAINE	NA	Kharkiv
205	Regional Clinical SpecializedDispensary for Radiation Protection of Citizenry	Neffa Maryna	UKRAINE	NA	Kharkiv
206	Beatson West Of Scotland Cancer Centre	MacPherson Iain	UNITED KINGDOM	GB-CBF	Glasgow
207	Western General Hospital	Oikonomidou Olga	UNITED KINGDOM	GB-EDH	Edinburgh
208	Churchill Hospital	Lord Simon	UNITED KINGDOM	GB-OXF	Torrance
209	University of Pittsburgh Medical Center - Hillman Cancer Ctr	Brufsky Adam	UNITED STATES	US-PA	PITTSBURGH
210	Michigan Medicine (University of Michigan)	Smerage Jeffrey	UNITED STATES	US-MI	Ann Arbor
211	Oncology Health Group	Betancourt Rafael	UNITED STATES	US-PR	Hato Rey
212	Siteman Cancer Center	MA Cynthia	UNITED STATES	US-MO	St Louise
213	Saint Luke's Hospital Of Kansas City	Pluard Timothy	UNITED STATES	US-MO	Kansas City
214	University of Iowa Hospitals and Clinics	VIKAS PRAVEEN	UNITED STATES	US-IA	Iowa City
215	Fort Wayne Medical Oncology and Hematology	Babu Sunil	UNITED STATES	US-IN	Fort Wayne
216	Wake Forest University Health Sciences	Thomas Alexandra	UNITED STATES	US-NC	Winston-Salem
217	NYU Langone Medical Center	NOVIK Yelena	UNITED STATES	US-NY	New York
218	University of Kansas Medical Center (KUMC)	Sharma Priyanka	UNITED STATES	US-KS	Westwood
219	Rutgers Cancer Institute	Omene Coral	UNITED STATES	US-NJ	New Brunswick
220	Northside Hospital Cancer Institute	Volas-Redd Gena	UNITED STATES	US-GA	Atlanta
221	Massachusetts General Hospital	Bardia Aditya	UNITED STATES	US-MA	Boston
222	Cleveland Clinic Florida	Samuel Thomas	UNITED STATES	US-FL	Fort Lauderdale
223	Cleveland Clinic Florida	Nahleh Zeina	UNITED STATES	US-FL	Fort Lauderdale
224	Stony Brook Hospital and Medical Center	Baer Lea	UNITED STATES	US-NY	Stony Brook
225	Stony Brook Hospital and Medical Center	Stopeck Alison	UNITED STATES	US-NY	Stony Brook
226	Valley Hospital	Teplinsky Eleonora	UNITED STATES	US-NJ	Paramus
227	University of Colorado	Kabos Peter	UNITED STATES	US-CO	Denver
228	University of Massachusetts	Toke Madhavi	UNITED STATES	US-MA	Worcester
229	Penn State Milton S. Hershey Medical Center	Truica Cristina	UNITED STATES	US-PA	HERSHEY
230	Maine Center for Cancer Medicine	Battelli Chiara	UNITED STATES	US-ME	Scarborough
231	UCLA Hematology Oncology Parkside	HURVITZ Sara	UNITED STATES	US-CA	Santa Monica
232	Regional Cancer Care Associates, LLC	Fang Bruno	UNITED STATES	US-NJ	East Brunswick
233	Lundquist Institute for Biomedical Innovation	Onyshchenko Mykola	UNITED STATES	US-CA	Torrance
234	Summit Cancer Care	Taylor Mark	UNITED STATES	US-GA	Savannah
235	Lewis Hall Singletary Oncology Center	Simmons Josh	UNITED STATES	US-GA	Thomasville
236	Olive View UCLA Medical Center	Chiu Victor	UNITED STATES	US-CA	Sylmar
237	Comprehensive Cancer Centers of Nevada	Christensen Stephani	UNITED STATES	US-NV	Henderson
238	St. Joseph Heritage Healthcare	LAWLER William	UNITED STATES	US-CA	Fullerton
239	University of Illinois at Chicago	Danciu Oana	UNITED STATES	US-IL	Chicago
240	Ucsf Comprehensive Ca Center	Rugo Hope	UNITED STATES	US-CA	San Francisco
241	Memorial Healthcare System	Milillo Naraine Adriana	UNITED STATES	US-FL	Hollywood
242	Bon Secours St. Francis Medical Center	Irvin William	UNITED STATES	US-VA	Midlothian
243	Virginia Commonwealth University	Ross Masey	UNITED STATES	US-VA	Richmond
244	Orlando Health, UF Health Cancer Center	Cuesta Fernandez Ana	UNITED STATES	US-FL	Orlando
245	West Virginia University	Salkeni Mohamad	UNITED STATES	US-WV	Morgantown
246	UCHealth Cancer Care and Hematology	SCHUSTER Steven	UNITED STATES	US-CO	Fort Collins
247	UCHealth Cancer Care and Hematology	Medgyesy Diana	UNITED STATES	US-CO	Fort Collins
248	UCHealth Medical Group Hematology/Oncology	Hoyer Robert	UNITED STATES	US-CO	Colorado Springs
249	PIH Health	Wang Lisa Shing-E Lu	UNITED STATES	US-CA	Whittier
250	AdventHealth Orlando	ALEMANY Carlos	UNITED STATES	US-FL	Orlando
251	New Jersey Cancer Care and Blood Disorders	ORSINI James	UNITED STATES	US-NJ	Belleville
252	University Cancer and Blood Center	SHEPHERD Cynthia	UNITED STATES	US-GA	Athens
253	Cancer and Blood Specialty Clinic	Abdulla Nihal	UNITED STATES	US-CA	Los Alamitos
254	NYU Langone- Winthrop	NOVIK Yelena	UNITED STATES	US-NY	Mineola
255	OptumCare Cancer Center	Gollard Russell	UNITED STATES	US-NV	Las Vegas
256	OptumCare Cancer Center	Jahangir Khawaja Saad	UNITED STATES	US-NV	Las Vegas
257	Watson Clinic	Mulaparthi Shalini	UNITED STATES	US-FL	Lakeland
258	Oklahoma Cancer Specialists and Research Institute	Moussa Ali	UNITED STATES	US-OK	Tulsa
259	Oncology Consultants	Alvarez Ricardo	UNITED STATES	US-TX	Houston
260	Illinois Cancer Care	Rehman Nadia	UNITED STATES	US-IL	Peoria
261	Texas Oncology - San Antonio	Aponte Emmalind	UNITED STATES	US-TX	San Antonio
262	Arizona Oncology Associates	Ahmed Aisha	UNITED STATES	US-AZ	Tucson
263	Northwest Cancer Specialists, P.C.	Andersen Jay	UNITED STATES	US-OR	Tigard
264	Texas Oncology - Memorial City	Cairo Michelina	UNITED STATES	US-TX	Houston
265	Shenandoah Oncology, P.C.	Houck, III William	UNITED STATES	US-VA	Winchester
266	Texas Oncology, PA	BLUM Joanne	UNITED STATES	US-TX	Dallas
267	Texas Oncology Baylor Sammons	Manhas Atisha	UNITED STATES	US-TX	Dallas
268	Texas Oncology - Methodest Dallas Cancer Center	MCINTYRE Kristi	UNITED STATES	US-TX	Dallas
269	Texas Oncology, PA	Patt Debra	UNITED STATES	US-TX	Austin
270	Texas Oncology, PA	Sanchez-Rivera Ines	UNITED STATES	US-TX	El Paso
271	Southern Cancer Center, P.C	Meshad Michael	UNITED STATES	US-AL	Daphne
272	Texas Oncology, P.A.	ENCARNACION Carlos	UNITED STATES	US-TX	Waco
273	Cancer Care Centers of Brevard, Inc	Kancharla Venkat Pavan	UNITED STATES	US-FL	Palm Bay
274	Texas Oncology - Deke Slayton Cancer Center	Kodali Dhatri	UNITED STATES	US-TX	Webster
275	Texas Oncology - Plano West	Kovoor Philip	UNITED STATES	US-TX	Plano
276	Illinois Cancer Specialists	Sobol Urszula	UNITED STATES	US-IL	Arlington Heights
277	Borsod-Abaúj-Zemplén Megyei Kzponti Kórház és Egyetemi Oktatókórház	Revesz Janos	HUNGARY	NA	Miskolc
278	Wielkopolskie Centrum Onkologii Oddzia Chemioterapii z Izb Przyjec im. Marii Skodowskiej-Curie	Kufel-Grabowska Joanna	Poznan	NA	POLAND
279	Wits Clinical Research Charlotte Maxeke Johannesburg Academic Hospital	DEMETRIOU Georgia	SOUTH AFRICA	NA	DEMETRIOU
280	The Medical Oncology Centre of Rosebank	Rapoport Bernardo	SOUTH AFRICA	NA	Rapoport
281	MERC SiReN	Yusuf MAYET	SOUTH AFRICA	NA	TAYOB (MAYET)
282	Cape Town Oncology Trials	JACOBS Conrad	SOUTH AFRICA	NA	JACOBS
283	Eastleigh Breast and Women's Health Centre	COCCIA-PORTUGAL Maria	SOUTH AFRICA	NA	COCCIA-PORTUGAL
284	Westrand Oncology Centre	GELDENHUYS D	SOUTH AFRICA	NA	GELDENHUYS

1	受试者有根治性手术治疗无效的局部复发或转移性疾病的证据
2	确诊ER阳性
3	确诊HER2阴性
4	未接受过全身性抗癌治疗的局部复发性或转移性乳腺癌患者
5	根据RECIST v.1.1可评价的可测量或不可测量疾病
6	东部肿瘤协作组（ECOG）体能状态（PS）为0-2分
7	能够签署知情同意书

1	已知有活动性脑转移的患者
2	既往（新）辅助治疗中使用过另一种选择性ER下调药物（SERD）。
3	器官或骨髓功能不全
4	在（新）辅助含芳香化酶抑制剂治疗期间或治疗结束后12个月内疾病复发。
5	怀孕，哺乳或者有生育能力的女性不愿使用建议的避孕办法
6	男性受试者不同意避孕
7	患者存在晚期、症状性内脏扩散，有短期内出现危及生命的并发症的风险
8	显著的合并疾病

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