评价来那度胺一线治疗多发性骨髓瘤的有效性和安全性

1
查找项目通过临床招募信息库查项目

2
联系我们招募专员进行初筛

3
签署同意签署知情同意书

4
成功入组成功参加临床试验

试验详情
入选标准
排除标准
研究中心

试验详情

一、临床试验项目名称
评价来那度胺一线治疗多发性骨髓瘤的有效性和安全性

二、适应症
多发性骨髓瘤

三、试验介绍

来那度胺与低剂量地塞米松联合疗法与美法仑、泼尼松、沙利度胺联合疗法在一线治疗多发性骨髓瘤的安全性及有效性对比

研究中心所在省份及城市（具体启动情况以后期咨询为准）

研究中心	主要研究者
Centre Hospitalier Regional Universitaire Hopital Claude Huriez Service des Maladies du Sang	Thierry FACON

序号	机构名称	主要研究者	国家	省（州）	城市
1	Centre Hospitalier Regional Universitaire Hopital Claude Huriez Service des Maladies du Sang	Thierry FACON	法国	无	Lille
2	北京大学人民医院	路瑾	中国	北京	北京
3	中国医学科学院北京协和医学院血液病医院（血液学研究所）	邱录贵	中国	天津	天津
4	北京朝阳医院	陈文明	中国	北京	北京
5	四川大学华西医院	刘霆	中国	四川	成都
6	上海交通大学医学院附属瑞金医院	沈志祥	中国	上海	上海
7	Gosford Hospital	Cecily Forsyth	Australia	NSW	Gosford
8	Wollongong Hospital	PeterPresgrave	Australia	NSW	Wollongong
9	The Royal Melbourne Hospital	JeffSzer	Australia	VIC	Parkville
10	Royal Brisbane and Women’s Hospital	SimonDurrant	Australia	QLD	Herston
11	Geelong Hospital	PhilipCampbell	Australia	VIC	Geelong
12	Princess Alexandra Hospital	PeterMollee	Australia	QLD	Woolloongabba
13	Flinders Medical Centre	DouglasCoghlan	Australia	SA	Bedford Park
14	Gold Coast Hospital	JeremyWellwood	Australia	QLD	Southport
15	Royal Perth Hospital	PaulCanniff	Australia	WA	Perth
16	Cabrini Hospital	Henry Miles Prince	Australia	WA	Malvern
17	Border Medical Oncology	RichardEek	Australia	VIC	Wodonga
18	Frankston Hospital	JohnCatalano	Australia	Frankston	Frankston
19	Royal Adelaide Hospital	NoemiHorvath	Australia	SA	Adelaide
20	Hospital Wels	JosefThaler	Austria	无	Wels
21	Hospital of Barmherzige Schwestern Linz	AndreasPetzer	Austria	无	Linz
22	Hospital of Elisabethinen Linz	HedwigKasparu	Austria	无	Linz
23	Peter MacCallum Cancer Centre Divsion of Haematology/Medical Oncology	SimonHarrison	Australia	VIC	E. Melbourne
24	Hospital Leoben	AngelikaPichler	Austria	无	Leoben
25	Western Hospital	WilliamRenwick	Australia	VIC	Footscray
26	Hospital of the Barmherzigen Brüder Vienna	JohannesMeran	Austria	无	Vienna
27	General Hospital Linz	MichaelFridrik	Austria	无	Linz
28	Hospital St. Polten	PeterBalcke	Austria	无	St. Polten
29	Hospital Wiener Neustadt	GerhardWeidinger	Austria	无	Wiener Neustadt
30	Westmead Hospital	AmandaJohnston	Australia	NSW	Wentworthville
31	MM-015.Wihelminenspital	HeinzLudwig	Austria	无	Vienna
32	MM-015. Medizinische Universit？t Wien	HeinzGisslinger	Austria	无	Vienna
33	MM-015. Salzburger Landkliniken, St. Johanns-Spital, Universit？tsklinik fur Innere Medizin III	RichardGreil	Austria	无	Salzburg
34	Cliniques Universitaires UCL de Mont-Godine	ChantalDoyen	Belgium	无	Yvoir
35	Jules Bordet Institut	NathalieMeuleman	Belgium	无	Brussel
36	Les Cliniques du Sud Luxembourg	PascalPierre	Belgium	无	Arlon
37	Cliniques Universitaires St-Luc	Marie-Christiane Vekemans	Belgium	无	Bruxelles
38	Hopital Erasme	WalterFeremans	Belgium	无	Brussels
39	H. Hartziekenhuis Roeselare-Menen vzw campus Wilgenstraat	HildeDemuynck	Belgium	无	Roeselare
40	Royal North Shore Hospital	NaomiMacKinlay	Australia	NSW	St Leonards
41	ZNA Stuivenberg Centrumziekenhuis	Ka LungWu	Belgium	无	Antwerpen
42	AZ Sint-Jan AV Brugge	Jan Van Droogenbroeck	Belgium	无	Brugge
43	AZ-VUB	RikSchots	Belgium	无	Brussels
44	Universitair Ziekenhuis Leuven, Campus Gasthuisberg	MichelDelforge	Belgium	无	Leuven
45	Universitair Ziekenhuis Gent	FritzOffner	Belgium	无	Gent
46	Virga Jesse Ziekenhuis	GreetBries	Belgium	无	Hasselt
47	Universitair Ziekenhuis Antwerpen	Ann Van de Velde	Belgium	无	Edegem
48	CH La Source	MadgaAlexis	France	无	Orleans
49	Centre Hospitalier	BrunoAnglaret	France	无	Valence
50	Institut Privé de Cancérologie	DavidAssouline	France	无	Grenoble
51	CHRU Hopital Purpan	MichelAttal	France	无	Toulouse cedex 9
52	CH Louis Pasteur	FaressHusseini	France	无	Colmar cedex
53	CU* ( CHU Clemenceau )	IsabelleAzais	France	无	Poitiers cedex
54	Centre Hospitalier de la c？te basqueHèmatologie	AnneBanos	France	无	Bayonne
55	Hopital Henri Mondor	KarimBelhadj	France	无	Creteil
56	CHRU Hopital Bretonneau	LotfiBenboubker	France	无	Tours cedex
57	CH René Dubois	RiadBenramdane	France	无	Cergy-Pontoise
58	Hopital Augustin Morvan	AdrianTempescul	France	无	Brest cedex
59	Hopital Antoine Béclère	FrancoisBoue	France	无	Clamart
60	Centre hospitalier de RoanneOncologie Médicale	NadineBoullanger	France	无	Roanne
61	GH de Institut Catholique St Vincent	ChristianRose	France	无	Lille
62	Institut Gustave Roussy	Jean-Henri Bourhis	France	无	Villejuif
63	Hopital Cochin	DidierBouscary	France	无	Paris Cedex 14
64	CHRU Hopital du bocage	DenisCaillot	France	无	Dijon
65	Hopital Avicenne	PhilippeCasassus	France	无	Bobigny Cedex
66	CHU ESTAING	BenoitDe Renzis	France	无	Clermont Ferrand
67	CH Argenteuil Victor Dupouy	Philippe C Genet	France	无	Argenteuil
68	Hopital d’instruction des armées Percy	Thierry De Revel	France	无	Clamart Cedex
69	Hopital Necker	RichardDelarue	France	无	Paris
70	CHRU Hopital du bocage	MamounDib	France	无	Angers cedex 01
71	Hopital de Mercy	VéroniqueDorvaux	France	无	METZ cedex 3
72	Institut Bergonié	GabrielEtienne	France	无	Bordeaux
73	Hopital Emile Muller	Jean-Claude Eisenmann	France	无	Mulhouse
74	CHRU-Hopital Claude Huriez	ThierryFacon	France	无	Lille cedex
75	Hopital Saint Louis	Jean-Paul Fermand	France	无	Paris
76	Polyclinique Bordeaux Nord Aquitaine	OlivierFitoussi	France	无	Bordeaux
77	Hopital de l'Archet 1	Jean-Gabriel Fuzibet	France	无	Nice cedex 3
78	CHU Hopital St-Antoine	LaurentGarderet	France	无	Paris
79	Clinique Claude BernardOncologie	Marie-Hélène Gaspard	France	无	Albi
80	Centre Léon Bérard	CatherineSebban	France	无	Lyon
81	CH	KamelGhomari	France	无	Beauvais
82	Centre René Huguenin	SylvieGlaisner	France	无	Saint Cloud
83	CHRU Hopital Trousseau	IsabelleGriffoul	France	无	Tours
84	CHRU Hopital sud Médecine Interne	OlivierDecaux	France	无	Rennes cedex 02
85	CHRU - Hotel Dieu	PhilippeMoreau	France	无	Nantes
86	CHRU Hopital de Hautepierre	RaoulHerbrecht	France	无	1 Avenue Molière
87	CHRU Hopitaux de Brabois	CyrilleHulin	France	无	Vandoeuvre cedex
88	CH - Hopital Dupuytren	ArnaudJaccard	France	无	Limoges Cedex 1
89	CH P. Chubert	HenryJardel	France	无	Vannes cedex
90	Institut de Cancerologie de Loire	JéromeJaubert	France	无	St Priest en Jarez
91	CH	RégisKaphan	France	无	Cannes Cedex
92	Hopital R. Debré	AnneQuinquenel	France	无	Reims cedex
93	CHRU Hopital de Pontchaillou	MartineEscoffre Barbe	France	无	Rennes Cedex
94	Centre Hospitalier	KamelLaribi	France	无	Le Mans cedex
95	Hopital de l'Archet 1	LaurenceLegros	France	无	Nice cedex 3
96	Centre Henri Becquerel	PascalLenain	France	无	Rouen cedex
97	Hospital Sainte Blandine	ElenaLoppinet	France	无	Metz
98	CH Jacques Coeur	AbdallahMaakaroun	France	无	Bouges
99	CHU	MargaretMacro	France	无	Caen
100	Centre Hospitalier Départemental	HervéMaisonneuve	France	无	La Roche -Sur-Yon cedex 9
101	Kremlin Bicêtre	StephanPavy	France	无	Le Kremlin bicetre CDX
102	CHRU - Hopital du Haut Lévêque	GéraldMarit	France	无	Pessac
103	CHU Hopital Edouard Herriot	MauricetteMichallet	France	无	Lyon cedex
104	Centre Hospitalier Yves Le Foll	OlivierAllangba	France	无	St-Brieuc cedex 1
105	CHG Rodez	LaurentMosser	France	无	Rodez
106	Hopital de Fleyriat	HubertOrfeuvre	France	无	Bourg en Bresse cedex
107	Centre Hospitalier de la Region d'Annecy	Frédérique Orsini Piocelle	France	无	Rodez
108	CHRU	BrigittePegourie	France	无	Grenoble cedex 09
109	CH	SophieRigaudeau	France	无	Le Chesnay cedex
110	Hopital Hotel Dieu	BernardRio	France	无	Paris cedex 04
111	Centre Hospitalier	El Yamani Abderrazik	France	无	Blois cedex
112	CHU Montpellier - H？pital Lapeyronie	Jean-Francois Rossi	France	无	Montpellier Cedex 5
113	CHU Sud	BrunoRoyer	France	无	Amiens
114	CHU Reims - Hopital Maison Blanche	Jean-Paul Eschard	France	无	Reims
115	CH - Sce Hématologie	Marc Simon	France	无	Valenciennes
116	Institut Paoli-Calmettes	Anne-Marie Stoppa	France	无	Marseille Cedex 9
117	Clinique Pont de chaume Oncologie et Radiothérapie	EtienneSuc	France	无	Montauban cedex
118	Centre Antoine Lacassagne Oncologie médicale et Hématologie	AntoineThyss	France	无	Nice cedex 1
119	Centre Hospitalier	GillesSalles	France	无	Lyon
120	Centre Francois Baclesse	Jean-Pierre Vilque	France	无	Caen cedex 5
121	Centre Hospitalier William Morey	LaurentVoillat	France	无	Chalon/Saone cedex
122	Centre Jean Bernard	EricVoog	France	无	Le Mans
123	Centre Hospitalier Général	MarcWetterwald	France	无	Dunkerque
124	Hopital J MonodRhumato Nord	CharlesZarnitsky	France	无	Le Havre
125	Medizinische Fakult？t der Universit？t Rostock	ChristianJunghanss	Germany	无	Rostock
126	Universitatsklinikum Essen-	UlrichDührsen	Germany	无	Essen
127	Universitaetsklinikum Dusseldorf Klinik fuer Haematologie	RolandFenk	Germany	无	Dusseldorf
128	Universitatsklinikum Giessen	MatthiasRummel	Germany	无	Giessen
129	Staedtische Kliniken Frankfurt am Main H？chst	H GuenterDerigs	Germany	无	Frankfurt am Main
130	Askepios Klinik St. Georg	MatthiasZeis	Germany	无	Hamburg
131	Zentrum F. Innere Medizin II Robert- Bosch-Krankenhaus GmBH	Walter Erich Aulitzky	Germany	无	Stuttgart
132	Universitatsklinikum Jena	Lars-OlofMügge	Germany	无	Jena
133	Klinikum der Johann-Wolfgang-Goethe-Universtat	Oliver G Ottmann	Germany	无	München
134	Medizinische Klinik III Klinikum der Universit？t München-Gro？hadern	HelmutOstermann	Germany	无	München
135	Poliklinik A	MartinKropff	Germany	无	Muenster
136	Universitatsklinikum schleswig-Holstein	FrankGieseler	Germany	无	Lübeck
137	Ernst-Moritz-Arndt-Universit？t Greifswald	GottfriedDolken	Germany	无	Greifswald
138	Medizinische Klinik und Poliklinik II	DietgerNiederwieser	Germany	无	Leipzig
139	Medizinische Klinik - Abteilung II	KatjaWeisel	Germany	无	Tübingen
140	Klinik fur Innere Medizin III	ChristianLanger	Germany	无	Ulm
141	Medizinische Kinik und Poliklinik I	ChristophRollig	Germany	无	Dresden
142	Alexandra Hospital, University of Athens	Meletios-AthansiosDimopoulos	Greece	无	Athens
143	Attiko Hospital of Athens	IoannisDevernoulas	Greece	无	Athens
144	Evangelismos Hospital of Athens	SosanaDelimpassi	Greece	无	Athens
145	University of Athens	Panagiotis Panagiotidis	Greece	无	Athens
146	Theagenio Anticancer Hospital of Thessaloniki	Konstantinos Zervas	Greece	无	Thessaloniki
147	Mater Misercordiae Hospital	Peter O Gorman	Ireland	无	Dublin
148	University Hospital Galway	MichaelO'Dwyer	Ireland	无	Galway
149	Adelaide and Meath Hospital	HelenEnright	Ireland	无	Dublin
150	Policlinico S. Orsola	MicheleCavo	Italy	无	Bologna
151	Policlinico San Matteo Universita Di Pavia	Alessandro Corso	Italy	无	Pavia 2
152	Ematologia ed Immunologia, Azienda Ospedaliera	NicolaDi Renzo	Italy	无	Lecce
153	Azienda Policlinico Umberto I, Università	RobertoFoa	Italy	无	Rome
154	Unità Operativa di Oncoematologia, Ospedale di Matera	AlbertoFragasso	Italy	无	Matera
155	Clinica Ematologica, A.O.U. San Martino di Genova	LetiziaCanepa	Italy	无	Genova
156	Istituto Europeo di Oncologia - IEO	GiovanniMartinelli	Italy	无	Milano
157	Arcispedale Santa Maria Nuova	BarbaraGamberi	Italy	无	Reggio Emilia
158	Casa di Cura	MaurizioMusso	Italy	无	Palermo
159	Ospedale Molinette	MarioBoccadoro	Italy	无	Torino
160	A.O. Universitaria Ospedale S.Chiara Dip.Oncologia, Div. Ematologia	MarioPetrini	Italy	无	Pisa
161	Oncoematologia, Istituto Nazionale Tumori Fondazione G. Pascale	AntonioPinto	Italy	无	Napoli
162	Istituto Nazionale Tumori Regina Elena, Struttura Complessa Ematologia ed Unita di Cellule Staminali	FrancescoD Pisani	Italy	无	Roma
163	Presidio Ospedaliero A. Perrino	AngelaMelpignano	Italy	无	Milano
164	Policlinico di Modena	StefanoSacchi	Italy	无	Modena
165	Oncologia Medica, Università della Magna Grecia	Pierfrancesco Tassone	Italy	无	Catanzaro
166	Ospedale Civile	AntonioLazzaro	Italy	无	Piacenza
167	U.O. di Ematologia e Trapianto di Midollo Osseo	FabioCiceri	Italy	无	Milano
168	Auckland City Hospital	PeterBrowett	New Zealand	无	Auckland
169	Wellington Hospital	KenRomeril	New Zealand	无	Newtown
170	Christchurch Hospital	AndrewButler	New Zealand	无	Christchurch
171	Instituto Português de Oncologia de Lisboa	JoanaPerreira	Portugal	无	Lisboa
172	Instituto Português de Oncologia Porto	AngeloMartins	Portugal	无	Porto
173	Hospital de Santa Maria	GracaEsteves	Portugal	无	Lisboa
174	Hospitais da Universidade de Coimbra	CatarinaGeraldes	Portugal	无	Coimbra
175	Hospital de Sao Marcos	MarquesHerlander	Portugal	无	Braga
176	Hospital de Santo Antonio- Porto	CristinaGoncalves	Portugal	无	Porto
177	Hospital 12 de Octubre	Juan José Lahuerta-Palacios	Spain	无	Madrid
178	Hospital Son Llatzer	Joan Bargay Lleonart	Spain	无	Palma de Mallorca
179	Hospital Clinico Santiago de Compostela	Marta Sonia Gonzalez Perez	Spain	无	Santiago de Compostela
180	Hospital Universtario Marques de Valdecilla	ArantxaBermudez	Spain	无	Santander
181	Hospital General Universitario Morales Messeguer	Felipe De Arriba de la Fuente	Spain	无	Murcia
182	Hospital Clinico San Carlos	Marta Mateos-Morales	Spain	无	Madrid
183	Hospital Univ. Josep Trueta	YolandaGonzales-Montes	Spain	无	Girona
184	Hospital Universitario La Paz	Ana Lopez de la Guia	Spain	无	Madrid
185	Hospital Germans Trias i Pujol	Albert Oriol Rocafigueira	Spain	无	Badalona (Barcelona)
186	Instituto Catalan de Oncologia-Hospital Duran	VictoriaClapés	Spain	无	Barcelona
187	Clinica Universitaria de Navarra,	Felipe Prosper-Cardoso	Spain	无	Pamplona
188	Hospital Clínico Virgen de la Victoria	GemmaRamírez	Spain	无	Málaga
189	Hospital Clínico Universitario de Valencia	AnabelTeruel Casasus	Spain	无	Valencia
190	Hospital de la Santa Creu i Sant Pau	MiguelGranell	Spain	无	Barcelona
191	Hospital Reina Sofia	AntonioTorres Gómez	Spain	无	Cordoba
192	Hospital Sant Pau	JosepGuma - Padro	Spain	无	Reus
193	Hosptial La Fe	Javier De la Rubia Comos	Spain	无	Valencia
194	Hospital Miguel Servet	Pilar Delgado	Spain	无	Zaragoza
195	Hospital de Donosti	AsunciónEcheveste - Gutierrez	Spain	无	Donostia
196	Hospital Clinico Universitario Lozano Blesa	LuisPalomera-Bernal	Spain	无	Zaragoza
197	Karolinska University Hospital Huddinge	HarethNahi	Sweden	无	Stockholm
198	Karolinska University HospitalSolna	AstridGruber	Sweden	无	Stockholm
199	Linkoping University Hospital	LuciaAhlberg	Sweden	无	Linkoping
200	St. Gorans Hospital	FredrikSjoo	Sweden	无	Stockholm
201	Centre Hospitalier Universitaire Vaudois (CHUV)	SergeLeyvraz (former Dr. Ketterer)	Switzerland	无	Lausanne
202	Inselsspital Bern	ThomasPabst	Switzerland	无	Berne
203	UniversitatsSpital Basel	DominikHeim	Switzerland	无	Basel
204	Abteilung Onkologie/Haematologie des Kantonsspitals Aarau	MarioBargetzi	Switzerland	无	Aarau
205	Kantonsspital Münsterlingen	ChristianTaverna	Switzerland	无	Münsterlingen (TG)
206	Kantonsspital Graubunden	RichardCathomas	Switzerland	无	Chur
207	Kantonsspital Winterthur	DanielBinder	Switzerland	无	Winterthur
208	Dept of Haematology St Bartholomews Hospital	JamieCavenagh	United Kingdom	无	London
209	Belfast City Hospital Haematology Department	MaryDrake	United Kingdom	无	Belfast Northern Ireland
210	Royal Hallamshire Hospital Sheffield Teaching Hospitals NHS Trust	YousefEzaydi	United Kingdom	无	Sheffield
211	Churchill Hospital	KarthikRamasamy	United Kingdom	无	Oxford
212	Royal United Hospital	Christopher Knechtli	United Kingdom	无	Bath
213	The Beatson West of Scotland Centre	GrantMcQuaker	United Kingdom	无	Glasgow
214	University Hospital of Wales - Cardiff	Christopher Fegan	United Kingdom	无	Cardiff
215	Royal Free Hospital	Atul B Mehta	United Kingdom	无	London
216	Bristol Haematology and Oncology Centre	JennyBird	United Kingdom	无	Bristol
217	Pinderfields General Hospital	JohnAshcroft	United Kingdom	无	West Yorkshire
218	Guy's and St Thomas' Hospital - London	Majid AliKazmi	United Kingdom	无	London
219	Derriford Hospital	HannahHunter	United Kingdom	无	Plymouth Crownhill Devon
220	Birminghman QE	MarkCook	United Kingdom	无	Birmingham West Midlands
221	Addenbrooke's Hospital	CharlesCrawley	United Kingdom	无	Cambridge
222	New Cross Hospital- Wolverhampton	SupratikBasu	United Kingdom	无	Wolverhampton
223	Royal Bournemouth Hosp	RachelHall	United Kingdom	无	Bournemouth Dorset
224	Gwynedd Hospital	JimSeale	United Kingdom	无	Bangor
225	Mayo Clinic Cancer Center	AngelaDispenzieri	USA	MN	Rochester
226	Fred Hutchinson Cancer Center	William Bensinger	USA	WA	Seattle
227	Stanford University Stanford	StevenCoutre	USA	CA	Stanford
228	Cedar Sinai Medical Center Dept of Medicine	RobertVescio	USA	CA	Los Angeles
229	Hospital Maisonneuve - Rosemont	RichardLeblanc	Canada	QC	Montreal
230	Center for Cancer and Blood Disorders	VictorPriego	USA	MD	Bethesda
231	University of California, San Francisco- California	ThomasG Martin	USA	CA	San Francisco
232	Southern Illinois Hematology /Oncology	JamesE Hays	USA	IL	Centralia
233	Swedish Cancer Institute	HenryKaplan	USA	WA	Seattle
234	University of Calgary	Nizar Jacques Bahlis	Canada	AB	Calgary
235	Hopital du Sacre-Coeur de Montreal	AxelTosikyan	Canada	QC	Montreal
236	Cross Cancer Institute	AndrewBelch	Canada	AB	Edmonton
237	McGill University	ChaimShustik	Canada	QC	Montreal
238	Leukemia/BMT Program of BCDiv of Hem, Vancouver Gen Hosp	KevinSong	Canada	BC	Vancouver
239	Princess Margaret Hospital	ChristineChen	Canada	ON	Toronto
240	Kaiser Permanente Northwest Oncology/Hematology	NegendraTirumali	USA	OR	Portland
241	Rush University Medical Center	StephanieA Gregory	USA	IL	Chicago
242	Cancer Center of Kansas	ShakerDakhil	USA	KS	Wichita
243	CHUM- Hopital Notre-Dame	BernardLemieux	Canada	QC	Montreal
244	London Health Science Centre	LeonardMinuk	Canada	ON	London
245	Burnaby Hospital Regional Cancer Center	WendyLam	Canada	BC	Burnaby
246	Dakota Cancer Institute	MahendraGupta	USA	ND	Fargo
247	Palm Beach Cancer Institute, LLC	RobertJacobson	USA	FL	West Palm Beach
248	CHUQ - Hotel-Dieu de QuebecHematology - Oncology	MarcLalancette	Canada	QC	Quebec
249	University of Texas Medical Branch	AviMarkowitz	USA	TX	Galveston
250	University of Pennsylvania	DanVogl	USA	PA	Philadelphia
251	Integrated Community Oncology Network	MehdiMoezi	USA	FL	Orange Park
252	Odette Cancer Centre	MatthewCheung	Canada	ON	Toronto
253	Queen Elizabeth II Health Sciences Center	DarrellJohn White	Canada	NS	Halifax
254	Royal Columbian Hospital	MichaelNoble	Canada	BC	New Westminster
255	The Cancer Center	DonaldGravenor	USA	TN	Collierville
256	University of Tennessee Cancer Institute	FurhanYunus	USA	TN	Memphis
257	Ottawa Hospital	RichardVan der Jagt	Canada	ON	Ottawa
258	Hospital Charles LeMoyne	PierreDesjardins	Canada	QC	Greenfield Park
259	Baptist Cancer Institute	Troy H Guthrie	USA	FL	Jacksonville
260	Hotel-Dieu de Levis	Felix Couture	Canada	QC	Levis
261	University of AL Birmingham	DiegoDe Idiaquez	USA	AL	Birmingham
262	Hopital de la Cite-de-la-Sante	NathalieAucoin	Canada	QC	Laval
263	British Columbia Cancer Agency	GregoryDueck	Canada	BC	Kelowna
264	Vancouver Island Cancer Center	JasonHart	Canada	BC	Victoria
265	Cleveland Clinic	FredericReu	USA	OH	Cleveland
266	St. Luke's Hospital and Health Network	HikaruNakajima	USA	PA	Allentown
267	Saint John Regional Hospital	Tony (Anthony James) Reiman	Canada	NB	Saint John
268	Juravinski Cancer Centre	Chrisostomos (Tom)Kouroukis	Canada	ON	Hamilton
269	Sir Mortimer B. Davis - Jewish Genl	SaritAssouline	Canada	QC	Montreal
270	BC Cancer Agency - Fraser Valley Centre	Abdulwalhab Al-Tourah	Canada	BC	Surrey
271	John H Stroger Hospital of Cook County	Rose Catchatourian	USA	IL	Chicago
272	University Hospitals of Cleveland	BrendaCooper	USA	OH	Cleveland
273	Gabrail Cancer Center	NashatGabrail	USA	OH	Canton
274	Billings Clinic	JorgeNieva	USA	MT	Billings
275	Ingalls Cancer Institute	MarkKozloff	USA	IL	Harvey
276	Gainesville Heme Oncology Associates	ManuelDe la Puerta	USA	FL	Gainesville
277	Orchard Healthcare Research, Inc.	StephanieWilliams	USA	IL	Chicago
278	Maine Center for Cancer Medicine/Blood Disorders	HelenRyan	USA	ME	Scarborough
279	Gulf Coast Oncology	JosephMace	USA	FL	St. Petersburg
280	Arena Oncology Associates, PC	RobertWeiner	USA	NY	Lake Success
281	Gachon University Gil Hospital	Jae HoonLee	Korea South	无	Incheon
282	Seoul National University Hospital	Sung sooYoon	Korea South	无	Seoul
283	National Cancer Center	Hyeon Seok Eom	Korea South	无	Gyeonggi-do
284	Hwasun Chonnam National University Hospital	Je-JungLee	Korea South	无	Hwasun-goon
285	Chungnam National University Hospital	Deog-Yeon Jo	Korea South	无	Daejon
286	Chonbuk National University Hospital 42	Jae-YongKwak	Korea South	无	Jeonju
287	Daegu Catholic University Medical Center 3056-6	Hun-MoRyoo	Korea South	无	Daegu
288	Seoul National University Bundang Hospital	Jeong-OkLee	Korea South	无	Seongnam
289	Severance Hospital	Soo Jeong Kim	Korea South	无	Seongsanno
290	The Catholic University of Korea Seoul	Chang KiMin	Korea South	无	Seoul
291	Asan Medical Center	Cheol wonSuh	Korea South	无	Seoul
292	Samsung Medical Center	KihyunKim	Korea South	无	Seoul
293	Inje University Busan Paik Hospital	Won-SikLee	Korea South	无	Busan
294	Ewha Womans University Mokdong Hospital	Yeung-Chul Mun	Korea South	无	Seoul
295	Hallym University Sacred Heart Hospital	Hyo JungKim	Korea South	无	Anyang
296	National Taiwan University Hospital	Shang-YiHuang	中国	无	Tapei
297	Chang Gung Medical Foundation, Kaohsiung Memorial Hospital	LoriKam	中国	无	Niao-Sung Hsiang Kaohsiung County
298	China Medical University Hospital	Su-PengYeh	中国	无	Taichung City
299	Veteran General Hospital - Taipei	Tzeon-JyeChiou	中国	无	Taipei
300	Chang Gung Medical Foundation, Linkou Memorial Hospital	Ming-Chung Kuo	中国	无	Kuei Shan Taoyuan County
301	Metaxa Hospital Peiraias	PanagiotisRepousis	Greece	无	Piraeus

1	1 必须知晓并自愿签署知情同意书
2	2 签署知情同意书时年龄大于等于18 岁
3	3 未经过既往治疗的MM症候，按以下3 个标准定义：
4	3.1 MM 诊断标准（符合所有 3 项）1：3.1.1 骨髓中单克隆浆细胞大于等于10％和/或存在经活检证实的浆细胞瘤; 3.1.2 血清和/或尿中存在单克隆蛋白; 3.1.3 多发性骨髓瘤相关器官功能障碍（至少下列之一）:[C] 血钙升高（血钙大于10.5 mg每dl 或至正常上限）[R] 肾功能不全（血清肌酐大于2 mg每dl）[A] 贫血（血红蛋白小于10 g每dl 或低于实验室正常值 2 g）[B] 溶骨性病灶或骨质疏松症 1 许多其他类型的终末器官功能障碍会偶尔发生并且需要治疗。这样的功能障碍如果证明与骨髓瘤有关，可用于界定为骨髓瘤。
5	3.2 同时存在蛋白电泳分析确认的疾病，定义如下：3.2.1 IgG 多发性骨髓瘤：血清单克隆异常蛋白（M 蛋白）水平大于等于1.0 g每dl 或尿 M 蛋白水平大于等于200 mg每24 h 3.2.2 IgA 多发性骨髓瘤：血清 M 蛋白水平大于等于 0.5 g/dl 或尿 M 蛋白水平大于等于200 mg/24 h 3.2.3 IgM 多发性骨髓瘤（IgM M 蛋白+骨骼检查平片报告的溶骨性骨骼疾病）：血清M蛋白水平大于等于1.0 g每dL或尿M蛋白水平大于等于200 mg每24 h 3.2.4 IgD 多发性骨髓瘤：血清M蛋白水平大于等于0.05 g每dl 或尿M蛋白水平大于等于200 mg每24 h 3.2.5 轻链型多发性骨髓瘤：血清M蛋白水平大于等于1.0 g/dl 或尿M蛋白水平大于等于200 mg每24 h
6	3.3 同时65 岁或以上，或者如果年龄小于 65岁，则是因为下列原因而不适合干细胞移植的患者：拒绝接受干细胞移植或由于费用或其他原因不能接受干细胞移植的患者
7	4. ECOG 体能状态为 0、1、或 2
8	5. 能遵守就诊时间和试验方案中要求
9	6. 可能受孕女性 (FCBP)2 必须：6.1 必须同意在开始Rd 或MPT 治疗研究前进行2 次医学监督下的妊娠检测。首次妊娠检测在Rd 或MPT 治疗开始前的10-14天内进行，第二次妊娠检测在Rd 或MPT 治疗开始前24 小时之内进行。她必须同意在研究期间和研究治疗结束后进行妊娠检测。此规定同样适用于进行完全且持续性禁欲的患者。6.2 必须同意在服用研究药物开始前28 天，研究治疗期间（包括用药暂停期间），及终止研究治疗后的28 天内坚持避免异性性交（必须按每个月审查），或者持续采用有效的避孕措施。2 FCBP 是指性成熟妇女：1）未曾进行子宫切除术或双侧卵巢切除术，或2）无至少连续24 个月（即在之前连续24 个月内的任何时间出现月经）自然地停经（癌症治疗后的闭经不能排除分娩可能）。
10	7. 男性患者必须：在整个研究药物治疗期，任何用药暂停期、和研究治疗停止后，即使已经进行了输精管切除术，必须同意在与FCBP 进行性交期间使用避孕套。必须同意在研究药物治疗期间和研究药物治疗结束后的一段时间不捐赠精液和精子。
11	8. 所有患者必须：了解研究药物可能有潜在的致畸危险。同意服用研究药物治疗期间和研究药物治疗停止后不捐献血液。同意不与他人分享研究药物。必须告诫所有FCBP和男性患者警惕妊娠及胎儿暴露于研究药物的风险。

1	曾经接受过抗骨髓瘤治疗（不包括放射放疗、双磷酸盐或单次短期激素治疗 [即小于或相当于地塞米松40mg每天，4 天的剂量；在入组14 天内不能进行这样的短期治疗]）。
2	任何会使参加本研究的患者遭受不可接受风险的严重疾病。此类医学状况包括但不限于不稳定性心脏病患者，定义为：过去6 个月内发生过诸如MI这样的心脏事件、NHYA Ⅲ-Ⅳ级心力衰竭、未得到控制的心房颤动或高血压；其状况需要长期类固醇或免疫抑制剂治疗，除研究治疗之外可能还需要类固醇或免疫抑制剂治疗的患者，例如风湿性关节炎、多发性硬化和狼疮患者。
3	妊娠或哺乳期女性。
4	以下任何一项实验室检测异常：嗜中性粒细胞绝对计数（ANC）小于1,000每mL（1.0 乘 10的9次方每L）；未经输血的血小板计数小于50,000 细胞每mL（50 乘 10的9次方每L）；血清SGOT或AST 或SGPT每ALT 大于正常值上限（ULN）的3.0 倍
5	需要血液透析或腹膜透析的肾衰。
6	除多发性骨髓瘤之外的恶性肿瘤病史，除非患者疾病治愈期大于等于3年。以下肿瘤疾病除外：皮肤基底细胞癌，鳞状上皮细胞癌，宫颈原位癌，乳腺原位癌，前列腺癌偶然组织学发现（TNM T1a 或T1b 期）
7	不能或不愿进行抗血栓治疗的患者
8	大于等于2 级的周围神经病变
9	已知HIV阳性，或甲肝、乙型肝炎或丙型肝炎感染期活动期患者，或乙型肝炎表面抗原（HBsAG）呈阳性的乙型肝炎慢性携带者，或聚合酶链反应（PCR）显示乙型肝炎病毒脱氧核糖核酸（HBV DNA）水平可测。
10	原发性AL（免疫球蛋白轻链）型淀粉样变性及骨髓瘤并发淀粉样变性。

相关临床试验招募信息

常见问题